I suffer from Polymyalgia Rheumatica. (PMR) an autoimmune disease. As with many autoimmunes steroids are used to treat it. Your symptoms fit steroid use. The test for cortisol is ACTH but the test is useless for testing cortisol until you get down to about 2-3mg of prednisone. Prednisone is an anti inflammatory and immune suppressant. Besides the list jeffmarc gave it raises blood pressure, raises cholesterol, raises A1C, causes gastric issues, floaters in the eyes, and bone density issues. Physical features such as moon face, thin skin, and weight gain. The worst thing is that after 2 weeks your body stops making cortisol. Prednisone is supplying it. You cannot live without cortisol. The bodies adrenal system will have to slowly restart while you taper off prednisone. The length of time and dosage of prednisone can effect this restart. You will go into extreme pain if you taper to quickly. Prednisone will fix a lot of issues but it is the devils tic tac. Google "prednisone and cortisol".

The reason I recommended more prednisone was because I thought your problem was fatigue. now that I review what you said I do not see that mentioned.

I’m not sure what changes you are referring to. I was speaking to someone yesterday who has major fatigue, problems, and hard time getting out of bed in the morning. he’s on 5 mg and a shortage of cortisol could be causing his problems, and more prednisone might fix it.

Not knowing the details of “changes in me” Makes it difficult to suggest anything. Maybe in your case you’re taking too much prednisone.

You definitely have to talk to your doctor and try to resolve this. You might consider getting a palliative care doctor. They work with people to resolve conflict with medicine they are taking that are causing them medical problems.