The Voltaren is an interesting topic. Even though it is a NSAID/Ibuprofen base, my Rheumatologist/P.A. instructed me to apply it to the pain areas four times per day. I reminded her that it was an NSAID and she replied' "It's on your skin". Isn't the skin the largest membrane of our body? I have applied it to my lower back area once or so daily, but not four times per day, but still conservative. I do really miss the Ibuprofen over the Acetaminophen for pain and irritation relief.