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PMR pain management with medical cannabis
Polymyalgia Rheumatica (PMR) | Last Active: Oct 23 11:39am | Replies (56)Comment receiving replies
You can read the comments made by oldbtstlshrp2 yesterday.
There is a drug interaction checker on Drugs.com. I checked to see if there was an interaction between cannabis and Prednisone and there was no reaction reported.
We are all individual - what works for me may not work for you. I have chosen low dose THC CBD/CBN gummies for sleep only because I think sleep is critical. Once my sleep is fully established and waking up without pain I will cut the gummies in half and maybe even quarter. My objective is to get off all medications, especially Prednisone.
Pain reprocessing therapy helps with all of that.
Replies to "You can read the comments made by oldbtstlshrp2 yesterday. There is a drug interaction checker on..."
I for the first time just tried those gummies …i was told to take one to see effects …it was amazing as I had 6 hours of uninterrupted sleep…will def . Use again
The Reaction is not from the THC, but the CBD content in Cannabis, different percentages by strains. For this reason there may be online; "No Reactions Shown". Any person wishing to use the Cannabis should observe the "Terpenes", their function for delivery of which compound and then take that into consideration for the Cannabis strain selected. Most people purchase Cannabis with the highest THC content, thinking it will work better and they get more relief-NOT TRUE! We have to be real careful when working with powerful side effects from Prednisone. CBD makes Prednisone Remain in our System Longer! UGLY.
If we come from a theoretical standpoint, there could potentially be drug interactions. Prednisone is a weak inducer, it is possible that it could change the breakdown or metabolism of CBD. It is something to be aware of.
CBD can inhibit the action of CYP3A4, a liver enzyme that metabolizes several kinds of drugs, including prednisone. Because of its inhibitory activity, it can cause the enzyme to slow down. This could cause the metabolism of prednisone to slow down as well, meaning prednisone would remain in the system for a longer time frame and more liable to cause more side effects.
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I've read this on a few sites - "Hydrocortisone and prednisolone, commonly used CS, are both metabolized by the cytochrome P450 enzyme CYP3A65. CBD, as potent inhibitor of CYP3A when with these steroids may decrease glucocorticoid clearance and increase risk of systemic CS-induced side effects as well,"