Unfortunately a positive Signatera indicates metastatic residual cancer, somewhere. By the way The test is identifying DNA from tumor cells somewhere but not cancer cells themselves, In other words cancer cells are not circulating in your blood. Is your doctor ordering a CT and MRI to try to find the location? In the meantime chemo is probably the best course. Data shows that Signatera can detect cancer up to 8 months before it can be seen on a CT or MRI. So if you can get back on chemo you may be able to head this off.