I tried taking ALA for a while, but it didn’t seem to improve my symptoms so I stopped after about a year, but I have either idiopathic small fiber neuropathy or suspected autoimmune, and I think the strongest research showed it benefited diabetic and chemotherapy induced neuropathy.

But since you had a positive experience before, hopefully you might again.

Perhaps you could consider a higher dose? It’s been a while but I was taking 600 mg because that was the dose that I saw had been studied. Just looked it up and found this: “ Taking 600-1800 mg of alpha-lipoic acid by mouth or by IV seems to improve symptoms such as burning, pain, and numbness in the legs and arms of people with diabetes. Lower doses of alpha-lipoic acid don't seem to work. IV products can only be given by a healthcare provider.”

From Web MD: https://www.webmd.com/vitamins/ai/ingredientmono-767/alpha-lipoic-acid

I used Vitamin Shoppe at the time because I read that it has a positive review from Consumer Lab but that was years ago now, and it wasn’t R-ALA.

So I can’t really recommend a “good” one that’s worked for me, since I don’t think it worked for me…

However, my PCP is an integrative medicine doctor and she recommends with supplements to go for reputable brands that are GMP certified. Thorne is prescription grade, used in studies, but it’s usually super expensive and I don’t think they have R-ALA.

She also approved of me taking a Jarrow Formulas supplement and that tends to be much more economical, and they do have R-ALA.

I didn’t know there was a difference, but I see that R-ALA is more absorbable so that could make it easier for our bodies to put it to use. Thanks for pointing that out.

I think it makes sense if you decide to do another trial, possibly with a higher dose, why not try R-ALA to give yourself a better chance it might work?