Thanks @windyshores! At 59 yrs and only 1 year into Letrozole for invasive lobular breast cancer, my endo recommended Fosamax which Ive been on for 8 months. I also have chrohns (inactive) and thought I was okay with side effects but most recently horrible pain in lower GI so I'm guessing the Fosamax in aggravating Chrohns. Oncologist suggested Zometa as you mentioned above but I wanted to start with oral weekly as had fewer side affects than the IV Reclast, Zometa. Now I'm just not sure and struggling who to talk to, GI doc, Endo or Oncologist. All so confusing. I'd like to just do a hard stop with Fosamax but Endo did emphasize that he was worried I could injure spine by even stepping off the curb. I live in Boston, walk a ton but really getting harder. Dana Farber in Boston is where my onco is and she would most likely tell me to try Zometa. I'll report back as I see her next month. xoxo