Family History of BPH causing PSA numbers to spike

Posted by jayhall @jayhall, Sep 25 8:35am

I've posted about my rising PSA numbers and if it's PC or just BPH causing the spike. I did some digging into my family history and found out that my dad starting having BPH and chronic prostate enlargement before he was 60, which is my current age. He was screened for PC and given multiple rounds of antibiotics to clear any infections. He tested negative for PC and his PSA numbers were "high". So I have hope that I just have what my dad did. Anyone else have a family history of BPH/high PSA numbers without PC?

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Good morning and thank you for your post. Given the limited information you have provided I can only make the following limited observations.
1) I think early on in the discovery of a rising PSA, we all hope with limited knowledge and understanding of the disease that it is simply “BPH” .
2) with regard to “your dad “not having PC, diagnostics and his day were very limited and often missed PC.
3) The most prudent advice I can give you is to follow protocols in assessing rising, PSA’s, which may include MRIs, appropriate, transparineal MRI guided biopsy or perhaps just “watchful waiting” Depending upon your clinical parameters. However, don’t be fooled into hoping too long and not exploring the appropriate diagnostic Work up. Because we know early diagnosis is linked to better outcomes if PC is discovered. Best of luck with your journey.

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Testosterone / estrogen ratios

Have a wholistic doctor, naturopath, primary care, or other doctor order labs for you and hopefully have useful suggestions. A good testosterone to estrogen ratio for a male that is 40 or older should be 8 to 10, though it is much higher in younger men. That is 8 to 10 times more testosterone than estrogen.

Symptoms of poor Testosterone / estrogen ratio in men include:

• BPH and sometimes prostate cancer follows
• Low libido
• Hair loss
• Weight gain & body fat
• Gynecomastia (“man-boobs”)
• Erectile dysfunction
• Muscle loss
• Fatigue

Things to do - knowing we are people with prostate problems including PCa.

• If PCa and BPH, don’t take exogenous testosterone (like injections) unless approved by physicians, so only work on natural was to raise the Testosterone portion of the ratio. That would mean exercise, controlling blood sugar, solving any zinc deficiency.
• Try things to lower estrogen. Some natural ways are cruciferous vegetables. Supplements include Sulforaphane glucosinolate (SGS) and DIM as these derive from cruciferous vegetables. Be sure the DIM and SGS work right for you, as they may not always do the job or an inadequate one.
• Avoid plastic touching food especially hot food, as it has “xenoestrogens” which to the body are just like estrogen. That means dump all plastic storage containers, especially older ones.
• Talk to your doctor about progesterone as it is a truly natural anti-estrogen. It is available OTC as well, but you need a low dose. Of course, use only a low dose suitable for men and doctors ordering labs to help. Trans-mucosal progesterone may produce best results.

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I had rising PSA and remembered my late father also had some prostate issues but never diagnosed with PCa.
Rising PSA became BPH and after Green Light Laser got about 5 yrs before cancer diagnosis.
I understand your feelings but wishful thinking is not helpful. Just follow the protocols, get all the tests, scans and biopsies - if necessary - and THEN maybe you can relax a bit. But for now, assume nothing and go with science.

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Over the course of about 6 years I had a very enlarged prostate and a fluctuating PSA. It would go anywhere from the low 3 to 7.7. My second Urologist told me that my high PSA was consistent with the volume of my prostate. I had an MRI an a biopsy in 2016, both came back detecting no cancer. I had a second MRI in late 2022 with the same result. I decided to have a second biopsy in mid 2023 which showed two cores of cancer out of 14; one of them at 3+4. I decided to have it robotically removed. The pathology report showed my core was actually 4+5, obviously putting me at a higher risk. Since then, I have had 3 PSA blood tests and all scored < 0.01. I have another blood draw next week and am hoping and praying for the same result. I’ve given you my history so you can see that anything can occur with PC. There is NO generic answer. Hopefully I’ve given you some more information that can help you with your decisions going forward. Best wishes!

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DO NOT ASSUME IT IS BPH .
I have BPH and am on Dutasteride to help shrink my prostate . If you are on any of these medications for 4 years or longer you multiply your lab PSA results by 2 times . That is if your lab PSA result is PSA 6 , it is really 12 .
I went through the antibotic stage for increasing PSA - eventually finished up with cancer .
Have a Digital Rectal Exam ( DRE ) , This may not find any leisons which are in a difficult locatiion .
Definetly have an MRI on a T- 3 machine not the old T - 1.5 Machines . .
Finally - Money well spent . Educate yourself on prostate cancer A to Z , by purchasing Dr. Patrick Walsh's 5th Edition book " Guide to Surviving Prostate Cancer . This will be the best money you ever spent and answer most or all of your questions.
Dr. Walsh is the worlds foremost authority on prostate cancer and a distinguished Professor Emeritus of Urology at John Hopkins Hospital in Baltimore, Maryland USA.

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