I developed chronic central pain syndrome following cervical surgery. It’s affecting my peripheral and central nervous system. I take 600mg gabapentin/3x/day, 30mg baclofen/3x/day and just started on 30mg duloxetine/1x/day. Both the gabapentin and the baclofen were started at low doses and gradually increased at 2-3 week intervals(especially the baclofen. With each additional medication and/or increase in dosage there is a period of side effects while my body adjusts but they haven’t been too bad and it’s somewhat hard to know what is a medication side effect or a new symptom.