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Prostate Cancer, Stage 4, spine & pelvis, Eligard, now abiraterone
Prostate Cancer | Last Active: Oct 5 9:35am | Replies (34)Comment receiving replies
Most people don’t have problems with liver enzymes. I was on abiraterone for 2 1/2 years and never had an issue, but they checked it every month.
I know some people have reduced it to three pills and even two pills and still had good results. For me, I reduced it to three pills and in 18 days, my PSA went from .2 to 1. Not very successful.
If you try to reduce it, make sure to get a PSA test real soon. With a Gleason nine your body may not like less than four pills.
After Abiraterone, when your PSA rises, you can try Darolutamide, it doesn’t affect the liver as much, normally, and the side effects are minimal for most people.
Replies to "Most people don’t have problems with liver enzymes. I was on abiraterone for 2 1/2 years..."
Thanks for your comments.
Yes, I have had to adjust my dosage to 3 abiraterone per day because of liver enzyme issues. However, my PSA has remained at 0.0 for the last 4 blood tests. Hopefully we hold that pattern. Although I was Gleason 9, it was localized and the PET scan showed no metastasis. I began with 30 days of photon radiation
Another thing you might research: there have been studies that show that 250 mgs of Abiraterone taken with a high fat breakfast results in the same blood absorption as 1,000 mgs taken after fasting.
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I recommend talking to your doctor about switching to Darolutamide. The efficacy of Daralutamide is outstanding and the clinical trials have consistently shown this drug out performs the other Androgen receptor signaling inhibitors (ARSI) (i.e., Abiraterone, Apalutamide, and Enzalutamide). For me personally, I would not want to be on prednisone for long periods of time. I understand I had to take prednisone daily while on chemo, but beyond that, I prefer not to be on prednisone for long periods of time. When I have asked why my fellow brother's that are stage 4 are not taking Darolutamide, the answer consistently is that their insurance will not pay for it. If your insurance pays for Darolutamide then consider talking to your provider. Darolutamide also does not break the blood brain barrier, so you will not have the brain fog that comes with the other ARSI's. I am a hard core software developer and since taking Eligard along with Darolutamide I have had no issues other than hot flashes and some fatigue.