Is this normal on ADT? Body hair gone

Just so — I agree. Words like "promising," "could," etc point to very early research. Most research like that doesn't work out, as you hint, so right now this isn't relevant to our treatment plans.

But I do appreciate @heavyphil sharing this, because the sheer number of "promising" results from different early studies helps keep me optimistic that at least a small number of them will make it through (even if we don't know yet which ones), and that we'll have yet more treatment options in 5 years or so. That makes it even more worthwhile putting up with the side-effects to keep us going until then.

You know, I think we all can agree that once you get the quality of life speech from your oncologist it’s basically game over for you.
Many have said that they’ll try Ivermectin and other off label or unproven means to stay alive - or at least ameliorate the pain from end stage PCa. Some are actually doing it.
My feeling is that sometimes a homeopathic approach just might work. I am highly allergic to poison ivy yet many sufferers take capsules containing ground up poison ivy to make them immune - and it works.
Once, in the midst of a terrible reaction, covered in an agonizing rash, an old farmer’s wife looked at me and laughed. “Hey Doc, thought you were smarter than that!” Registering my confusion she said, “When my kids were just babies I FED THEM poison ivy leaves in salad every spring and not one of them ever got what you got.” I almost fell over imagining these poor tykes with swollen tongues and throats being rushed to the ER. But she claimed that didn’t happen.
So when we learn that testosterone is our enemy couldn’t it be possible that in many instances it could be our friend? Why do men get PCa when their T is on the wane instead of when it’s raging in our younger years?
What’s different? What changed?
I am very encouraged by this novel approach and I hope they continue their research. If I was a candidate I would certainly go for it. The worst that happens is that the cancer grows - evidenced by careful PSA monitoring and it doesn’t work just like nothing else did. Russian Roulette? Perhaps, but I really had nothing to lose since I was circling the drain anyway and the quality of life had become unbearable. Just my personal opinion and not an endorsement or criticism of anyone’s life choices.

Hi @heavyphil, just got your message. I believe this is the article from Duke Health that you're referring to.

- Study Solves Testosterone’s Paradoxical Effects in Prostate Cancer https://corporate.dukehealth.org/news/study-solves-testosterones-paradoxical-effects-prostate-cancer

and this is the link to the published journal article:
- Androgen receptor monomers and dimers regulate opposing biological processes in prostate cancer cells https://www.nature.com/articles/s41467-024-52032-y

I'm encouraged by research that helps to determine which conditions are required for treatment to be most effective and matching patients to the most suitable and effective treatments.

You make it sound like you are having an awful lot of problems.

Have the drugs failed you, and does your PSA keeps rising?

Have you had chemo or Pluvicto?

Are you having pain from metastasis you have?

If they are in the bone, have you tried radium 223?

Over at the Ancan.org support group there are hundreds of people involved but as one would suspect with that many people some of them don’t make it. The people that run the support group try to help as much as they can, considering they have 15 years of experience, helping people make decisions about what to do next. They might be able to help you, they are aware of almost everything going on in the industry right now.. There’s a meeting tomorrow night 6pm to 8pm eastern. New people get helped first. Something to consider.

In response to both "heavyphil" and "jeffmarc",
Yes, very interesting article and comments.
As I read this very short article of a complicated issue I gathered from the context that the patients they selected had very aggressive PC and were selected for this reason; to get some control of the PC. Of course this is my opinion for their selection process rather than some unmentioned 'biomarker' or more detail in the actual study report.
I'm hoping their further research leads to a more effective as well as reduced side effects treatment protocol for all of us and those yet to be diagnosed.
Fingers crossed my brothers!

No, Jeff, I am doing fine! My comments were meant as a follow up to @aldenrobert who has had such a go of it, all his treatments failing and rightfully discouraged about future treatment.
I mentioned the article about the paradoxical effects of T on PCa and how it might be something he would like to explore since all attempts to lower his T have not been successful.
Perhaps you could send your post to HIM as a private message. The support group you mention must have people in it who have been in similar straits and could help him decide on his next course of treatment. Thanks!
Phil