I am on a DOAC - Xarelto - for Factor 5 clotting and it has worked well for me with one huge exception. I had an eye surgery in 2018 to insert a drainage tube for glaucoma. Two hematologists told me to stop the Xarelto for two days beforehand, but I stopped it for four days just out of caution. There was a bleed at the surgery and then about a month later, the day of my post-surgical checkup, everything went black and there was a huge pain in my head. I thought I was having a stroke and went to my appt. By that time a little vision had returned. I was reassured that everything still looked okay, looked good in fact, but before I left the building it all turned black again. My eye wall had collapsed from a huge bleed.
Two surgeries to drain blood followed and I kept being assured that the blood would reabsorb or be drained but that didn't happen. My hematologist explained that Factor V makes a very tough clot.
A retina specialist explained to me that all these - I think he called them neo-nics - drugs are very problematic for surgery, because the veins in the eye are tiny and weak. He said you need to be off them for ten days before surgery even if you don't have a genetic clotting disorder. When I asked him how he knew this, he said retina specialists work with a lot of older eye patients who need eye surgery and he had seen this happen before. I saw him for a couple of years and although there was a teeny improvement, basically I lost that eye. You don't want to be 80 years old and lose an eye; six years later I still have mixed dominance, no depth perception, and am quite off balance in general.
If you're on these drugs and need eye surgery, ask a LOT of questions.