I'm not sure if one is really better than the other, they're both nasty drugs but some women feel better on one vs the other (kinda like one AI vs another AI). However, its important to check with your insurance b/c some only cover one or the other, some will cover both drugs, but given how expensive it is, you want to make sure its covered first. I also found that some doctors only offer either lupron or zoladex simply b/c thats the only one they usually stock in their office.