Here in the United States the NCCN sets the guidelines for how long ADT should be used after radiation. For an Gleason eight they recommend 18 months Gleason nine or 10 they recommend 24 months.

Your treatment does seem to exceed US guidelines, but they are trying to prevent the cancer from coming back, continuing the treatment for as long as you are going to have it gives you the best chance.

With intraductal and cribriform you really are high-risk. Those two things really decrease longevity. You may actually end up being on the drugs longer than they are now recommending. You just have to wait and see what happens.

I’ve been on ADT for seven years, my BRCA2 genetic problem has the PSA pop back up the minute I reduce anything I’m taking. I was on Lupron and four Zytiga every day for 2.5 years. Brain fog was a pain so I tried to reduce my Zytiga to three pills. In 18 days, my PSA went from .2 to 1. We just have to live with what our bodies give us the best results. I am now on Darolutamide and have been undetectable for 10 months. Studies have shown that Zytiga is the drug to start with, and when it fails, move on to the ludamides. Something to keep in mind for the future.