@cb772 Ketamine is normally used in sedation but has also been used as a party drug over the years. Several years ago, it was found to help people with severe depression. The initial infusion can help reduce suicidal thoughts and depression very quickly and is often used that way now in emergency rooms. The more interesting treatment, though, is through a series of six or so IV infusions over a two week period. These infusions may or may not work but have about 70-80% chance of helping a person. Most people don't feel any relief for the first few infusions but towards the 5th or 6th, they start feeling better if it is going to work. I felt better after my 5th and much better after the 6th. The idea with this type of treatment is called neuroplasticity and is using the ketamine to help rewrite the neurons in the brain. I go back in for a single infusion every three months. I am not currently on any anti-depressant or anti-anxiety meds. At one point, my psychiatrist had me on an overdose level of Parnate and Olanzapine in addition to ECTs. I am one of the success stories for ketamine. One of the issues with ketamine is that different clinics will do different things. A single dose or two really won't do much long term. You really do need to start off with the series and then have the upkeep treatments. There is a nasal version that was put out recently but I am a little dubious of it since it only uses one of the two ketamine molecules. It is by prescription so that may be a good reason to try it (insurance covers it) but the response isn't as good as the IV series.