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The first 4 months I was on Orgovyx I was getting one or two hot flashes a day maximum. After I was on it for five months I started getting more hot flashes. I’m now getting between five and nine hot flashes a day. I use my Embr Wave device at night and that pretty much keeps the hot flashes down while sleeping. I had to start using the fan and my wave device during the day again.
With the wave device if I don’t hit the button right away when I start feeling the hot flash, then it does build some, so the fan helps. Problem is, you can’t always tell when it’s starting to come on, or I am doing something and I can’t hit the button right away.
I pay nothing for Orgovyx. With my insurance if I get a Lupron shot every six months they charge me $400. Crazy!!
I switched from Firmagon (Degarelix) to Orgovyx (Relugolix) a few months ago. As the shared "-lix" suffix suggests, they are related — both are GnRH receptor antagonists — but just switching from monthly injections to daily pills has made a huge improvement in my quality of life.
I've never taken a GnRH receptor modulator like Eligard/Lupron (Leuprorelin), so I can't compare there, but yes, I'd *never* want to go back to megadosing big monthly injections unless I had no other medical choice. I'm really surprised at how big a difference it makes spreading it out in smaller, daily doses.