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Constant excruciating leg cramps

Chronic Pain | Last Active: Sep 26 3:42pm | Replies (97)
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@annie1

I have excruciating spasms and twitching after decompression surgery in March. I had Stenosis for 7 years prior to surgery. A new Dr told me to take 2-3 Gaba at bedtime. I was afraid to take that much at the same time. Also, I had literally two sips of wine. Will I die ?(haha) but the internet says I could.
Not sure if I should take that much. Any thoughts and also interaction with wine or Oxycodone ?
Thank you,
annie

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Replies to "I have excruciating spasms and twitching after decompression surgery in March. I had Stenosis for 7..."
tabuschlen | @tabuschlen | Sep 25 1:35pm

I feel happy that your doctor knows about GABA. That's not gabapentin, but GABA.

I have taken that dose and not even felt sleepy, but my body stopped the spasm. Occasionally it makes me tired. Other people might get very tired from that dose.

I wouldn't ever want to give you medical advice, that's your doctors job.
I found a pub med article to explain the interaction between opioid and gaba.
https://pubmed.ncbi.nlm.nih.gov/9403690/#:~:text=Opioids%20inhibit%20GABA%2Dmediated%20(GABAergic,the%20mechanisms%20involved%20remain%20uncertain.
Please be cautious.

I know people that removed the alcohol and opioid, and just take health food store gaba for pain. Opioid withdrawal is a thing, and I would recommend expert advice as I have no personal experience with this.

GABA and the GABA system does change the effects of the opioid , please use extreme caution.

This appears to be evolving research.
Must talk to Dr, and not mix this stuff until there's a plan for you from your dr, is my advice, that's not medical, but caution.
https://pubmed.ncbi.nlm.nih.gov/6139983/
https://www.pnas.org/doi/10.1073/pnas.1915143117

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