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Is this normal on ADT? Body hair gone
Prostate Cancer | Last Active: Sep 23 2:56pm | Replies (76)Comment receiving replies
I've made the same decision not to try pausing ADT.
The last research I read about suggested that ADT "vacations" are safe for earlier stages of PCa (and might even improve overall survival slightly), but resulted in lower overall survival for advanced PCa like mine.
Since ADT and ARSI have been keeping my PSA undetectable for three years so far — with manageable side effects — I'm not willing to risk taking a "vacation" and maybe seeing my cancer come back as castrate-resistant after a few months. It would be like poking a sleeping bear with a stick. 🙂
It's still early days, though. New research and evidence might. change my mind in the future.
Replies to "I've made the same decision not to try pausing ADT. The last research I read about..."
Checked with my friend who went to the PCRI conference and sure enough taking Zytiga for more than four years also causes neuroendocrine cancer, which is pretty much not treatable yet.
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A warning. At the latest PCRI conference, they announced that they have found that being on one of the lutamides (Enzalutamide, apalutamide, Darolutamide) for four years can cause small cell neuroendocrine cancer. a cancer that is pretty much untreatable and leads to death within a year or less.
I don’t recall if Zytiga was included in this. I will find out.
It’s not guaranteed, but it’s a danger to be aware of.