There was some old research that alternate day dosing was helpful when a patient had adrenal insufficiency. Supposedly when your cortisol level drops low enough without a replacement dose of Prednisone that would be a clue for the adrenals to produce cortisol. I don't think those studies were ever validated.

I tried doing alternate day dosing when I thought PMR was in remission. It wasn't that drastic but I wouldn't recommend doing that if you are still having symptoms. My endocrinologist wasn't opposed to me trying alternate day dosing but not as a fixed schedule if I started to have symptoms on the day I didn't take my dose. My endocrinoloist warned me that it could be dangerous if my adrenals weren't able to produce enough cortisol.

Also, I was on a biologic that controlled PMR when I tried alternate day dosing.