I also had and have such a positive experience with Pure Pancreatin Enzymes. I take them religiously when I eat. I also brought them to my Gastro Doc. and she said they were fine to replace the Creon. They actually seem to work better for my body. My EPI has given me no problems. Occasionally I overdue, but it clears up when I go back to bland foods for a day and keep taking my enzymes. I also thought i had IBS...nope! These enzymes seemed to clear up any stomach, digestive issues.