I would think you might need more than 2.5 mg of prednisone before starting Kevzara. It takes a few months for the effects of Kevzara to start working. You still need to taper off Prednisone slowly because your cortisol level is probably very low after 5 years on Prednisone.

I was started on a different biologic than Kevzara. It eventually worked but it still took me more than a year to get off Prednisone completely. I was still taking 10 mg of prednisone as my "lowest effective dose" before starting the biologic.