My husband has had both chemotherapy with docetaxel and very recent therapy with Pluvicto.
Pluvicto infusions, their effect on the immune system, and their side effects, are NOT like chemo infusions. The infusion itself doesn't take very long, around an hour. The side effects are much milder than those caused by chemotherapy. Most patients experience a dry mouth and dry eyes, and some have gastrointestinal side effects such as constipation or mild nausea. These are easily treated with Miralax and Zofran, respectively. Food doesn't taste terrible or metallic or chemical like after chemotherapy; it just isn't very appealing, and the patient may have a reduced appetite. Pluvicto doesn't have the same effect on the immune system as chemotherapy either. Lab tests are used to monitor whether the infusions are causing trouble with red blood cells, liver function, kidney function, etc. and the dose or interval of the infusions can be adjusted if necessary. My husband had lab tests a few hours to the day before each infusion, and then three weeks after each infusion, which is midway between one infusion and the next. He just finished his sixth and final Pluvicto infusion and never had lab results which caused a modification or delay in his treatments. Finally, please don't worry too much about radiation danger. It is preferable to sleep in separate beds and use separate bathrooms if possible for a few days, and to avoid having young children or pregnant people near the patient for a week or so. But there is no problem riding home together in a car after treatment, or flying home after treatment, or staying in a hotel after treatment. Your nuclear medicine team will have specific instructions for you to follow to minimize radiation exposure to others. Please don't think you need to buy a Geiger counter or isolate the patient for a week, as some men have argued on this forum. Do a search on the Prostate Cancer support group of Mayo Connect for Pluvicto entries, and pay special attention to the helpful entries by Colleen, who moderates the group for Mayo Clinic. She has laid out the current advice on radiation safely post-Pluvicto.

Please feel free to ask any other questions you have. Good luck to you both, and keep us posted.