Welcome to Connect, @sennep! We have a growing number of members in our BMT support group. The field of bone marrow transplantation continues to evolve, in part, through the research and data collected from patients willing to participate in a program. Each of us who have undergone a BMT/SCT are here because someone else went before us. These procedures have been gaining a good track record for potential cures for some forms of leukemia, autoimmune diseases, etc..

But there is still work to be done in the fine tuning of some of the potential side effects such graft vs host disease where the new immune system finds it diffcult to ‘play nice’ with it’s host…the body in which the stem cells have been infused.
My transplant was 5 years ago and it’s amazing how much has evolved since then. I had the standard methotrexate and tacrolimus post transplant. I did really well though there were some gvhd events. They were handled quickly by my team and at post 5 years I’m very healthy, active and feel 99% of my former self. I was 65 at the time, so, now 70 and feeling amazing.
Over that 5 years time, meds such as Cyclophosphamide, Itacitnib and abatcept have been added to the protocol to help prevent acute GVHD and also help prevent chronic GVHD. From my understanding each of these meds, some in combination have been pretty successful in their mission.

One of our more recent BMT members, @katgob had post transplant protocol for GVHD with a trial med to avoid GVHD. Maybe she can tell you a little more about her experience. She’s around 160+ days post? Anyway, she’s off the tacrolimus and from my undertanding doing really well with no GVHD issues!

This article from Ash Publications talks about the progress made in pre-treating GVHD
https://ashpublications.org/hematology/article/2018/1/228/277593/Current-approaches-to-prevent-and-treat-GVHD-after
If you’re having a haploidentical transplant, is your donor a sibling, child or parent? If you don’t mind sharing more about yourself, what condition has brought you to needing a transplant? Do you have any questions about the transplant?