@dooshie this is a great question with no definitive answer for it in my opinion. Many members on this forum shared their bone markers at baseline as well as during various therapies. Since bone markers vary greatly among individuals at baseline and they repond in various degrees during therapy at individual level, i think monitoring trends after the start of a therapy is very useful.

Your set of p1np 74 and ctx 420 is from a recent lab, or ~2 months after finishing tymlos, right? Do you have btm lab at the end of tymlos therapy? If you do, you could compare them. Use my case as an example, I started hrt right after finishing forteo. The lab was done right before the start of hrt and one month after. It showed ctx had 28% reduction to 572 and p1np stayed at 150, which is nice for me to know the resorption went down quite a bit while formation marker didn't change. The btms will be monitored periodically to see if hrt dose needs to be adjusted. Hope you have a set of btms to compare with to see how they trend. But otherwise from your absolute numbers they look OK to me - p1np in the upper half of the range and ctx closer to 300s. One thing for sure, hrt will prevent bone loss to certain degree - it's a matter of dose and whether other secondary cause(s) of op is involved and under control. Hope other members chime in with their opinions. Take it easy and enjoy your trip!