We use Honeywell 2 stage air purifiers, a large one in the living room & a smaller one in our bedroom. They use a prefilter that catches odors, most dust and pet hair, and separate HEPA filters for small particulates. This is in addition to a whole house HEPA system on our HVAC. We have a smaller one in our tiny house in Texas, and will be purchasing one for our camper yet this fall.
I read all the reviews before I bought, concluded that most of the good filters were very closely matched in their ability to trap pollution, and chose the Honeywell for 2 very pragmatic reasons - they have been around forever and use standardized filter - so are readily available in a multipack. And they have signal lights that tell me when to change them. Even though the prefilters are supposed to be good for 3 months, I usually need to change them more often.
My kids each bought top-rated HEPA filters from new manufacturers a few years ago, and both companies are gone. When they use up their current supply of filters, they will need to buy new machines. And one has a pre-filter that requires weekly vacuuming - no way I want to be exposing myself to that.

The 99.97% HEPA filters, not matter the brand, should capture NTM and just about every other bacteria, not pass it through.

When it is time to change the filters, I mask up, take a bag to the machine, drop in the old filters and tie it shut. That minimizes exposure, and any chance of shaking contaminants loose around the house.