← Return to Bone turnover markers (CTX and P1NP): do you have a baseline?

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@kristie2

Before I started Evenity my numbers were CTX 933, P1NP 77.
After 1 year and before starting Prolia P1NP 25 . My MD put in a wrong lab of NTx which was 8.7 . She then ordered the corrected lab but it was a week after starting Prolia and it was 39 . From my understanding Prolia can drop these numbers even after a week .
I will do follow up labs in 3-4 months .

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Replies to "Before I started Evenity my numbers were CTX 933, P1NP 77. After 1 year and before..."

@kristie2 the set of btms that you did before evenity could be served as your new baseline for prolia therapy for future comparison I think. Too bad ctx was missed but I suspect it being much lower than your original baseline prior to any osteodrug therapy, since currently you have HRT at work as a backgroud also. Your ctx reading of 39 one week into prolia most likely is within expectation. This is an excerpt from btm substudy of Freedom trial for denosumab (prolia):

"The changes in bone-resorption markers with denosumab do not remain steady over the dosing interval; there is suppression within 12 hours of administration of the drug, with median decreases in bone-resorption markers of 80% or more. There is subsequently a resolution of effect before the next injection, and this cycle of marked reduction followed by a release in bone turnover markers (BTMs) occurs after each injection"

As the authors stated, the btms decreased 80% or more within 12 hours after prolia injection - your 39 ctx reading is expected, except you don't have a pre treatment value to compare with.

Wish the plan you and your endo picked works out great for you. Thank you very much for sharing your journey along the way!