@normahorn Thanks for suggesting this excellent article. It's about the efforts to try to optimize dosing for cancer drugs but it applies pretty well to osteoporosis drugs. In the article it's patients, doctors and researchers trying to find effective lower doses and reduce side effects for cancer patients. Seems to me that for osteoporosis it's the patients fighting for this and researchers are not involved.

There was at least one book which may be 10-15 years old now that proposed that the standard doses of pharmaceuticals in general were excessive. I never read the book though I thought about it often. I do not remember the name of it. If anyone knows of books on this topic I'd appreciate your input.