@bluebonnet242 i think these are great numbers at 2-3mo Tymlos' therapy! Tymlos doesn't increase ctx that much so your number is within expectation when compared with results in clinical trials. The more important p1np increased 116% which is wonderful!

According to literatures, after a fracture the significant increase in bone markers is during first few weeks. Ctx could peak at 4 weeks while p1np at 12 weeks after a fracture. Later on both markers could stay elevated throughout the healing process. Since it's been more than 6mo since your fracture, your p1np jump most likely is due to Tymlos' effect. Thank you very much for sharing your therapy progress. Best wishes to you!