I have been on Anastrazole for 5+ years now. ER+ breast cancer. 19 lymph nodes removed at age 68. The Anastrazole reduces my risk of recurrence of breast cancer by at least 50% my oncologist tells me. Now they are supporting continued use of AI meds if patient can tolerate and that is my plan. Other than being very difficult to lose weight (common with estrogen suppressant meds) I have had no other issues. I have worked with my pcp to take meds that are NOT hormone based ( the new wonder diet drugs are hormone based) and I Have lost 40 pounds since initial diagnosis. I want to lose another 20 pounds. The chemo And breast docs both agree that weight reduction and continued use of anastrazole will reduce my risk of recurrence. Pre versus post menopausal status may make a big difference so careful discussion with doctors is critical. JMHO!