Reclast affect on Evenity ?

Thank you. I'm hoping my visit with her answers some of my questions 🙂 But this will be a short appt, so we shall see.

Here is an article on bone markers (and chornic kidney disease)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628199/
and an excerpt:
For these reasons, especially in CKD, it is important to realize that estimating bone turnover by measuring circulating biomarkers is full of pitfalls, that even a reliable estimate of turnover does not indicate changes in bone balance, and that fracture risk is also dependent on bone features that cannot be assessed by biomarkers, nor even by bone histomorphometry like architecture and bone strength

@255anny I thought Evenity was only ever allowed for one year and that was it forevermore. Did you hear otherwise? I finished Evenity and now looking at starting Reclast or Prolia and wondering if that means I can never go back to Evenity. Any insights you have appreciated!

@mayapath2health
I was led to believe that evenity was a one year only. Not to be repeated. That is what I did and now probably doing reclast which is my doctors choice for me.

@mayapath2health Have you been told what the acceptable gap time is between finishing Evenity and starting Reclast? Thanks so much.

@susanjohnston Endo office that administered Evenity recommends I start either Prolia or Reclast at 4 weeks. Not sure if that is standard or not.

@mayapath2health Thanks so much.

@gently I see this is from a year ago but I’m hoping you wouldn’t mind expanding. If I did Reclast for one year before Forteo or possibly Evenity is that a better route than straight to Forteo? ( I couldn’t tolerate the alendronate. )So I guess I’d know if I could tolerate the Reclast when also needed for a relay drug. I have very low bone density in spine (-4.5) with fractures so want to do the best possible way.
Thanks for any input from the wise folks on this site.
I see the specialist in a week.

brendammc,
the low bone density would make Evenity a consideration. It adds bone the most quickly and could give you a scaffolding effect protecting you from fracture. Personally I would go straight to Forteo, even so. But think you should give Evenity a thought considering where you've fractured and looking carefully at the accuracy of the -4.5.
Each of these drugs create a different quality of bone
Forteo just creates the best bone, the strongest and most resilient. It is one of the two medications that reconstruct the cartilage structure in the spinal vertebra. Fracture protection begins more quickly than bone density with Forteo use.
Evenity increases bone density the fastest. And it is amazing. The bone lain down is heavier without the communication channels that make integrative bone. It doesn't repair the inner layer of bone, but lays the bone on (against) the outside of existing bone. It's only tempting to me where the bone is likely to fracture very soon.
I wouldn't consider Reclast because it is just too slow. It builds bone by collecting it over time. I like that it protects against further loss, but it can't repair older fissured bone,.
The mechanism of both Reclast and Evenity prevent the repair of bone that I think you need at -4.5.

Another complication with Evenity is what do you take after it, because that bone is lost within a year.
Some few are taking a second year of Evenity. Others are following with Reclast and, of course, Amgen wants you to take Prolia.
Some agile doctors are prescribing Tymlos following Evenity which seems (from individual reports here) to be maintaining the Evenity-bone.
Remember though that I'm just a fellow traveler without the scientific background of our doctors. I hope that the truly wise will contradict me. And hope that you feel free to contact me.
Blessing your choice.

Which one of these can cause kidney issues?