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← Return to Evenity and Bone Markers
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@marymj7 I had bone markers twice trying to catch bone growth, without success. P1NP may go up the first week or two. I got tested at the end of the first month and no change in P1NP, nor was there change in the middle of the third month. I have no idea what that means but doctor thinks I missed the best time to test: probably at the end of the 2nd week.
Your P1NP is lower than mine (my baseline is in the 50's and every test, whether at 18 months with Tymlos or with Evenity, it remains there). Would love to know what you get now. Evenity may be mostly anti-resorptive at this point, according to my doc.
I have not found bone markers to be helpful but it is all in the timing.
Replies to "@marymj7 I had bone markers twice trying to catch bone growth, without success. P1NP may go..."
You have been so informative in so many ways! My current situation is that I have been on Tymlos for about five months. My current pen runs out in days. Our insurance company (commercial) changed with the new year, and the new company is denying the necessity of Tymlos, wanting me to use a bisphosonate. Conversations are taking place to try to get them to reconsider (long process and many layers of people). Also, the doctor I was seeing in the practice left for another part of the country, and I have a doc that is new-to-me in the practice (and she is an osteoporosis-concentrated doc). She wants me to see her in mid Feb (first available I guess) and do labs prior “to see if Tymlos is even working”. Labs include bone markers, which I assume is what she will focus on. I did have all this done prior to beginning Tymlos. She declines giving me one of their sample pens so I will not have to discontinue treatment. So it appears she too is questioning my need for Tymlos……(or they want to save them for people in greater need and risk, which I understand).
I have scheduled my labs asap, so if being off the med adversely affects the markers. But is it reasonable to hinge my treatment plan on bone markers five months in? (I know you are not a doctor, and I will not quote you or in any way consider you responsible for anything. I just am wondering how reasonable this is and if I should question it). I am 62, in great health aside from this. Spine dexa the worst at -3.6, but no fractures. I do have probs with acid reflux, and that is why my PCP said I needed to see an osteo doc, as she can’t prescribe other than old school stuff. Thx to you and anyone else who can comment.
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@windyshores Thanks so much for your response. I'm afraid the dexa scan is my only way to see if it worked after going through all 12 shots. Even that is dicey, as my last Dexa one year ago was done 3 months after a moderate L4 fracture, thus throwing off the numbers. I have had unexpected dental issues crop up-so I would definitely get off Evenity if it's not working. I didn't know that the anti resorptive phase kicked in so quickly. I know once I follow with a bisphosphonate I can't have extractions, which is scary. I had to get off of Tymlos due to hypercalciuria, which I still have at baseline, to a less extent than when on Tymlos.