Hello. I gained 12 pounds over a 6-month period while on an antidepressant (Mirtazapine) for bipolar depression. The medication worked extremely well for the depression but I had to stop taking Mirtazapine due to the weight gain. I am now on Wellbutrin which is an antidepressant that is supposed to help with weight loss. However, at the same time, I was also put on Abilify and have had an increase in appetite which caused me to gain a couple of pounds. Through disciplined eating and exercise, I have been able to lose 5 pounds by exercising at least four times per week and trying to watch what I eat. I asked my psychiatrist for the lowest dosage of Abilify. I currently take a half of a 2mg tablet of Abilify.