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Reclast affect on Evenity ?

Osteoporosis & Bone Health | Last Active: Sep 11 5:12am | Replies (12)

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@gently

255anny,
Evenity's effect may be blunted by prior use of Reclast, but it will increase bone density after Reclast. The deposition of bone with Evenity is almost all modeling which doesn't involve the osteoclasts that are efficiently blunted by Reclast. Evenity's mechanism of action is different than the bisphosphonates as it increases the number of osteoblasts.
You might advantage the measured effect of Evenity by delaying treatment, but the delay wouldn't advantage the total effect on your bones.
Some doctors say that one year of Reclast has the same effect at two years as two consecutive years of Reclast.
You'd have additional fracture risk prevention if you had the Evenity injections after the first year of Reclast.
If you were at high fracture risk, you might not want to wait that extra year.
Bone markers are always wise. I'd have them before, and at three months.

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Replies to "255anny, Evenity's effect may be blunted by prior use of Reclast, but it will increase bone..."

Thank you - your explanation is what I was looking for :-).
I am very high fracture risk, so I would not want to wait for that additional year to start the Evenity.