Hi @vidya2, Mayo-Rochester is my home away from home. I think you’ll find everyone at the Clinic very welcoming and supportive. There are volunteers in Blue Vests on every floor who can help direct you or answer questions if you need help.
The buildings are all interconnected with easy directional sighs to help you find your way around. If you take the elevators down the S floor, all of the buildings flow into each other without having to go outside.
Here’s a link to the maps of the building and subway systems
https://www.mayoclinic.org/patient-visitor-guide/minnesota/campus-buildings-maps
Rochester is relatively small and easy to navigate. The clinic is in the heart of the city with hotels, restaurants/ shopping all nearby. Many of the hotels connect to the ‘subway’ which is a lovely underground/skyway walking system,

If there’s anything I can help you with, just let me know. Are you all set with lodging?