thank you all for sharing your experiences and insights. I am currently on the prowl for hormone doctor. I am 67, live in San Diego and was done with menopause before I knew I started at age 47. Took bioidenticals until 58. Transdermal. I tapered off naturally. Now I am interested in going back to regain stamina and muscles. Just nothing happens at PT when I try to build muscle. And the fascia sticks together. So far, no one has been supportive at UCSD so I will look outside. I am not so interested in the pellets for the reason @teb described above. When I used the transdermal I had total control and liked that. It also seems a lot less expensive. I also thought it would help support bones. I did one round reclast (with HORRID reaction) and one Tymlos for 5 months now and have great results! Thank you for sharing!