I tried 3, and then gave up. That was 4 years ago. I still cannot bend my fingers and have problems with my feet. Brain fog, depression, and crippling side effects are what made me stop. I took it for 6 month and the joint pain was immediate. My eyesite is an ongoing issue, and right now I suffer dry eyes. I felt and still feel today that this drug has not proven itself necessary, when you still have to go through radiation, and sometimes chemo. I did radiation and I am finishing my 5th year cancer free. These tyrials are not done with the patient at the forefront, and are run through by big Pharma. The fillers in these drugs are crippling. I am happy I stopped when I did. I still dont know for sure the amount of damage done to my body in the long term. Some people can take these with no issues showing right away. I was not one of them.