Just another note on Hydroxychloroquine. My understanding is that it is an immunosuppressant, just like Methotrexate and Leflunomide but not as strong and therefore better tolerated by those with drug sensitivities. Dose is based on your weight, I started on half the recommended dose because I am very sensitive to medications, started noticing within about 6 weeks that it was helping with the Prednisone reductions. I bumped it up by 100mg on one occasion over the last 6 months when it felt like the PMR was flaring and it helped me avoid increasing Prednisone. The main side effect of concern is irreversible changes in the retina of the eye but this only happens when you've been taking it for about 5 years. I like the fact that the low level of immune suppression allows my natural immune system to continue functioning. Have healed well after minor skin surgery and respiratory illnesses. It gets a thumbs up from me.