I am sorry he has developed ascites.
After a stage 2 diagnosis at Mayo, followed by 12 Folfirinox cycles, with checks at Mayo every two months showing some improvement, and then five weeks of radiation - all in advance of a scheduled Whipple surgery at Mayo, my sister, age 64, developed ascites. She had weakened progressively over this time.
Given ascites the surgeon said they could not operate, and that if able, she should return home for additional chemo, but she was hospitalized following the next session, then stayed in rehab for two weeks during which there was continuing metastasis to her peritoneum and possibly lungs, until she returned home for hospice care. She passed two months later.
Here is a reasonable, but specific, resource on pancreatic cancer and ascites. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060830/#:~:text=In%20a%20study%20with%20180,instance%2C%20both%20Zervos%20et%20al.
Thank you for the information. I’m sorry for the loss of your sister to this terrible disease. Did she show signs of metastasis before the ascites?