@bethiemae
I have Hashimoto’s and hypothyroidism after having my right thyroid lobe removed due to a large suspicious nodule (2.5 cm). I have been taking 100 mcg of Levothyroxine for the last year but was started on 75 mcg in late 2022. Before this, I was diagnosed with small fiber neuropathy (SFN) in 2017 and now have peripheral neuropathy in arms/hands, legs/feet. In 2017, I started taking alpha Lipoic acid and Acetyl l carnitine for my SFN. I was also diagnosed with gastritis and esophagitis (caused by too much NSAIDs for chronic pain over 10 years) at the end of 2023 and started taking omeprazole 20 mg. My gastroenterologist and surgeon who will be taking my no -functioning gallbladder out told me that alpha Lipoic acid does not cause increased acid in your stomach.

What matters is when you take your medicines/supplements for best absorption and not interfere with each other. I take my levothyroxine in the middle of the night when I get up to go to the bathroom. This ensures a window of time to allow for it to be absorbed on an empty stomach (should be 2-4 hours before/after a meal or taking other medications). When I wake up, I take the Omeprazole 30 minutes before eating and then take my other medications after eating. A change in the acid in your stomach can affect absorption. I take my alpha Lipoic acid at night after dinner and have had no issues. My bigger problem is needing to cut back on caffeine which affect my stomach more than anything else. I have tried to cut way back on NSAIDs and switched to Tylenol for pain. There are times I still need to take an NSAID or use a muscle/arthritis cream for inflammation but I still try to use less than I would in the past.

Good luck!