There are general recommendations and medical protocols for a Prednisone dose reduction schedule but if you read through some of the posts on this site on the topic of 'tapering' you will find that many of us have to work out for ourselves what we can tolerate. The simple general rule of thumb is no more than 1mg per month. How you do that is up to you. I tried several different reduction schedules and found that reducing by 0.25mg in weekly intervals was the least stressful on my body. Many people cope with a 1mg drop with only minimal adjustment aches and pains. However if you experience a significant ramping up of pain and stiffness, go back to your previous dose and stay on it for another few weeks before trying again. The goal is to achieve a slow steady reduction in dose, without flaring up the inflammation, allowing your adrenal gland to start producing its own cortisol again. It's a delicate balancing act which requires you to be tuned in to all the factors that could be influencing the inflammation response.