I was diagnosed with peripheral neuropathy about 1 year ago with foot and lower leg numbness plus occasional body tremors. My neurologist did a B6 test which showed that mine was too high but I was only taking 25 mg per day which is supposed to be safe. The doctor told me to immediately stop all supplements with B6. It took about 3 months but I finally got back to normal and PN went away. The P5P version of B6 is supposed to be less likely to accumulate in the body but if you happen to have the MTHFR gene mutation which as many as 40% of people of European descent supposedly do, your body absorbs too much B6 so it may not be safe to take any version of B6. Also, watch our for fortified foods like cereal because many of them had B6 added to them.