Definitely haven’t experienced this; I’m sorry it’s happening to you. I’m no expert, but I did a lot of research and thought long and hard about starting LDN because I’m sensitive to medications, and I don’t recall it being a common side effect, but with skin issues, its always possible. And itching could be a nervous system response too.

Sounds like a good idea to try discontinuing it and then resuming to see if it comes back. If you know you have allergies it may be worth asking the compounding pharmacy for a list of ingredients?

Did you state straight off at 4.5 mg or did you titrate slowly from a lower dose? (Pre-Long COVID, starting slowly and increasing was usually how it was done but now that more providers are more willing to prescribe it, I’ve noticed others mentioning to me it was prescribed to them straight off at a higher dose. That could theoretically cause more side effects. I was originally prescribed it for fatigue for a different condition.)