Is Reclast just 1 dose or has to be multiple?

Posted by 255anny @255anny, Sep 2 8:45am

I need to understand the dosing of Reclast better. I am coming off Evenity and need further medication. Can Reclast be used as 1 dose, then I would follow up with another drug (hopefully Evenity again) Or does Reclast need to given for a longer length of time, say up to 3 years? Is just one dose enough to lock in gains?

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Reclast can be given for one year. Hidden in my last, long post the doctor says he almost never gives the second year of Reclast.
Evenity following Reclast might have some interesting advantages expecially in the first months when it it thought to be primarily anabolic. Because the anabolic mechanism is different bone growth may not be blunted the way it is when following Reclast with Forteo or Tymlos.
https://link.springer.com/article/10.1007/s00198-020-05502-0

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I recently finished my 12 months of Evenity. 1 month later I had my Reclast infusion. My rheumatologist hasn’t decided whether we’re going to do 2 or 3 years of it yet. I had 2 years of it prior to Evenity and the max you can have is 5 years. I honestly don’t know what comes next for me. So I would think you need more than one year (dose). Good luck!

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@gammyb

I recently finished my 12 months of Evenity. 1 month later I had my Reclast infusion. My rheumatologist hasn’t decided whether we’re going to do 2 or 3 years of it yet. I had 2 years of it prior to Evenity and the max you can have is 5 years. I honestly don’t know what comes next for me. So I would think you need more than one year (dose). Good luck!

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thank you! If you don't mind me asking, since you have a bit of experience with the Reclast, did you have any adverse reactions?

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@255anny

thank you! If you don't mind me asking, since you have a bit of experience with the Reclast, did you have any adverse reactions?

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I didn’t have any reactions at all. I don’t get a lot of side effects that I hear other people get. No idea why but I’m thankful.

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@255anny I'm only on shot 11 of Evenity so this isn't based on personal lived experience but I think 1 Reclast would be all you need if you indeed return to Evenity. There is a study that repeated Evenity. In one group there was a year with Prolia and in the other group there was just a placebo. Then another year of Evenity. The result was modest gains in spine and break even in hips for Evenity following Prolia. The Evenity group that followed the placebo had almost identical gains compared to their first Evenity round (which was around 12% spinal in both cases).
So they proved that 1 year between Evenity rounds was sufficient and that Evenity could prevent a crash after Prolia.
I guess my thinking is that as long as you have a gap in time Evenity can return to it's full power. So the purpose of a med following Evenity (if returning to Evenity) would not be to lock in gains forever but to prevent loses during the gap in time to allow your body to utilize Evenity fully once again. So no need for 3 years of Reclast or any med if it is just providing a safe gap between Evenity doses. My fear besides possibly reacting to Reclast is that it will be to powerful an antiresorptive so that just one dose hinders the upcoming Evenity round. Hope this all
makes sense.
Here's that paper I'm referring to: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399468/

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During the year, after the first Reclast infusion, is there a need for CTX to be monitored?

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@255anny

During the year, after the first Reclast infusion, is there a need for CTX to be monitored?

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Yes

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