Please ask your rheumatologist or any of your healthcare pros for genetic testing. Genesight is what my doctor used, and only one of the antidepressant drugs was suitable for me. My sister had been on a myriad of different drugs over a 20 year span and nothing had been optimal treatment until she was gene-tested and the best drug was found suited to her makeup. And , of course, no surprise that the same drug was best for us both. Good luck!