I have been taking hydroxychloroquine for 18 years for another autoimmune disease, but it did nothing for the PMR pain. Same thing with methotrexate. But, it might help for you, each medication works differently on different people.

@lindaadel
I encourage you to suggest a biologic to your rheumatologist. I’m on a monthly infusion of Actemra along with a daily dose of 5 mg of prednisone (down from 15 mg three months ago). My inflammation markers have dropped to normal, and my PMR pain has been replaced with the normal aches and stiffness of a senior citizen. Next month I’m going to begin tapering off of the prednisone. I believe the Actemra made the difference.

I tried Methotrexate and reacted badly but many others find it helpful. Hydroxychloroquine has worked for me with no discernible side effects and at a relatively low dose. I had quite severe PMR and it has dramatically lowered my CRP inflammation score over 6 months of taking it. I have been able to steadily decrease the Prednisone dose, now at 3.25mg (plan o be at zero by xmas), pain levels are managed with a couple of Paracetamol a few times a week. As with all these drugs, it takes a few months to start working. My Rheumatologist said I will probably need to keep taking it for at least 2 years. I think I can get off it much sooner by keeping up the AI diet and exercise regime.

@lindaadel, you have received some helpful replies to your question about treating PMR with hydroxychloroquine. Additionally, I moved your question to this existing discussion so that you can review previous comments and connect with other members:
- Treating PMR with Prednisone and Hydroxychloroquine: https://connect.mayoclinic.org/discussion/treating-pmr-with-prednisone-and-hydroxychloroquine/

Has your rheumatologist suggest that hydroxychloroquine might work better for you?