Gleason7(3+4) - treatment options recommendation

Posted by manojsmishra @manojsmishra, Aug 25 3:42pm

Got recently diagnosed with Gleason group 2, 7(3+4). Was in state of shock to know about the cancer.
I’m 56 year old and fortunately I’m with Mayo care since last decade.
Recommendation for me is to have prostatectomy as radiation therapy has long term implications. Took outside opinion also and same recommendation. But not sure how to deal post procedure with urge to urinate situation currently there.
Biggest thing is I’m hoping there is no recurrence occurring after this. Any suggestion/recommendation?

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@vancouverislandhiker

Sir , you have a great writing style . Your information and advise was very sage. I think also treatment options to consider is age . At 56 I was diagnosed . Steep family history of this Cancer. I pulled the sheets over my father head 24 years ago from PC, and I can still see him . He was a good man, a good dad . I know have the same disease as my dad . Back then , my dad went with external radiation therapy . At 60 he got radiation and died at 67 . Very young in retrospect. I was more proactive with my health because of his experience. After the Operation for me in March 2021, my PSA did not zero out but hung around 0.1 or so . at 0.14 ( about a year ago ) I got External Beam Radiation (EBRT) for 22 session. Nothing happened really until about 7 months , then my PSA went from 0.14 to 0.072 , last PSA was at 0.056 ( one year level) . The trend is my friend here . My next PSA is in 2.5 weeks . I have PST I think from looking after my Dad . I was his care giver when he was sick . I am loosing sleep over the next PSA in 2.5 weeks . I know its silly and im trending great ....but how will I feel if the PSA data point is higher than 0.056 ? I know ).056 is a very low number but I have seen guys in my support group go to zero from here and also a one guy I know rebounded to 1.2 PSA ! Ouch ! I dont know what I would do ... Anyway , God Bless Sir . James on Vancouver Island .

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Best wishes on your next PSA results! Please let us know how it comes out.

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Roger Sir ! Yes I think they should rename the PSA test to " patient source of anxiety" . Lordy !!! I dont get great sleep about 10 days prior . SO , I will take it Mid Sept. The tend has been good and I need it to continue . The whole anxiety situation is more or less from dealing with my father and his prostate discovery about 28 years ago or so. I remember it like yesterday. He was a chemical engineer and a very bright guy, but he hated going to the doctors as he said it was not an exact science and they can get you into trouble. When he had to get a physical for an overseas trip, they snagged him at that point. I think he was at 14 to 17 on the PSA. Who knows how long he had it for. He was 60 at the time. One year younger than myself. I drove him to his appointment and cancelled him and gave him books on topic, etc. The last year was the toughest. He elected to do External beam radiation as his only treatment. Then he went on hormone therapy prior to his death about one year. That was tough to witness. I would come up to the hospital in the palliative care ward and bring some of his favourite foods or treats, at times he would smile and other times he would smile and say, "...I wish I had the appetite and my taste buds to eat that ..." . It was like yesterday for sure Sir . God Bless you and yours . . James on Vancouver Island .

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@manojsmishra

@vancouverislandhiker
First of all thank you for your kind words. I am glad to know that my writing style is appreciated.
In case of prostatectomy the PSA should be flat like upto 0.1 but it will never be zero. That question I did ask my U/O after my biopsy results review. Looking at what you shared I don’t think you need to worry
At my age group generally prostatectomy most patients opt for but I want
To evaluate all options first. I am also hearing that Gleason G2 now are also candidate for surveillance something I’ll check with my doctors also

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Thanks Sir . I have talked to some Operation guys that have had 0.008 ( bottom of readings and unreadable) for years and years , but most have a trace after surgery , you are right . A year ago, I elected to have the external beam radiation, 22 sessions, and I really didn't get any reaction until about the seventh month level. Then it started to go down from 0.14, 0.072, 0.056. Now, in 2 1/2 weeks I'll get another one. Battle is keeping my head straight and not getting too much anxiety. I'm going for a sauna this morning here on Vancouver Island, and talking with the boys up there at the Aquatic Center, and then some yardwork and then, I have a hike planned with my wife at 4 PM with the dogs for about 3 1/2 hours. Keeping busy helps. The exercise is great and the fresh air. While I was getting the 22 sessions of radiation, I would walk for 8 to 10 km each day. Yes I was tired, but it kept my mind active and I went through a ton of neighbourhoods and areas in Victoria area. Yes, you have time and I think because you are a 3+4 I think you said, you have plenty of options. Depending on the type of four cell, I don't think you have too much to worry about. You said you were Group 2-7 ? With a PSA of 3+4 = 7 . I understand the PSA , But the Group 2-7 we dont use too much in Canada - what is the groupings all about ? From my Prostate support group, the vast majority of patients with 3+4 Gleeson have responded very well to the operation and the radiation. I think the trick here is catching it early when your PSA velocity starts to rise. God Bless Sir . James on Vancouver Island .

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@vancouverislandhiker

Thanks Sir . I have talked to some Operation guys that have had 0.008 ( bottom of readings and unreadable) for years and years , but most have a trace after surgery , you are right . A year ago, I elected to have the external beam radiation, 22 sessions, and I really didn't get any reaction until about the seventh month level. Then it started to go down from 0.14, 0.072, 0.056. Now, in 2 1/2 weeks I'll get another one. Battle is keeping my head straight and not getting too much anxiety. I'm going for a sauna this morning here on Vancouver Island, and talking with the boys up there at the Aquatic Center, and then some yardwork and then, I have a hike planned with my wife at 4 PM with the dogs for about 3 1/2 hours. Keeping busy helps. The exercise is great and the fresh air. While I was getting the 22 sessions of radiation, I would walk for 8 to 10 km each day. Yes I was tired, but it kept my mind active and I went through a ton of neighbourhoods and areas in Victoria area. Yes, you have time and I think because you are a 3+4 I think you said, you have plenty of options. Depending on the type of four cell, I don't think you have too much to worry about. You said you were Group 2-7 ? With a PSA of 3+4 = 7 . I understand the PSA , But the Group 2-7 we dont use too much in Canada - what is the groupings all about ? From my Prostate support group, the vast majority of patients with 3+4 Gleeson have responded very well to the operation and the radiation. I think the trick here is catching it early when your PSA velocity starts to rise. God Bless Sir . James on Vancouver Island .

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Well PSA is one of the indicator for early detection like in my case. That’s how I ended up learning about the situation. It kept bouncing up and down over last 2 years but this year it was 5.14 and my pcp suggested for urology visit. As there is no symptom, I was reasonably sure that even if I do mri for this analysis I should be okay. That’s how I discovered this. Thanks you Mayo Clinic higher standards and advanced equipments.
Now I will be evaluating all options while I scheduled for surgery Oct 30

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Today I met with doctor for focal therapy treatment option. It seems this is offered to selected patients that qualify in certain criteria. I fall in this category but this is HIFU(Hi intensity Focal Ultrasound) offered as clinical trial.
This does not give me comfort on the treatment outcomes but if any one went this route, I’ll be interested in learning their experience

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@vancouverislandhiker

Sir , you have a great writing style . Your information and advise was very sage. I think also treatment options to consider is age . At 56 I was diagnosed . Steep family history of this Cancer. I pulled the sheets over my father head 24 years ago from PC, and I can still see him . He was a good man, a good dad . I know have the same disease as my dad . Back then , my dad went with external radiation therapy . At 60 he got radiation and died at 67 . Very young in retrospect. I was more proactive with my health because of his experience. After the Operation for me in March 2021, my PSA did not zero out but hung around 0.1 or so . at 0.14 ( about a year ago ) I got External Beam Radiation (EBRT) for 22 session. Nothing happened really until about 7 months , then my PSA went from 0.14 to 0.072 , last PSA was at 0.056 ( one year level) . The trend is my friend here . My next PSA is in 2.5 weeks . I have PST I think from looking after my Dad . I was his care giver when he was sick . I am loosing sleep over the next PSA in 2.5 weeks . I know its silly and im trending great ....but how will I feel if the PSA data point is higher than 0.056 ? I know ).056 is a very low number but I have seen guys in my support group go to zero from here and also a one guy I know rebounded to 1.2 PSA ! Ouch ! I dont know what I would do ... Anyway , God Bless Sir . James on Vancouver Island .

Jump to this post

Yup, that fear and anxiety NEVER goes away even if it’s ZERO.
I was on pins and needles for 5 yrs watching my PSA slowly creep upwards. Now that I have been put on Orgovyx and am scheduled for 25 radiation sessions I actually feel better!
To fiddle while Rome is burning is the worst for me. Of course, what if the PSA starts to climb again after all this??! My wife begs me to stop projecting but it sure ain’t easy…
Best of luck - the trend IS your friend!

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I have empathy for you. Just getting the prostate news is very difficult to deal with. There are many ways for you to deal with your situation. Good luck as you decide and manage your situation.

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@vancouverislandhiker

Roger Sir ! Yes I think they should rename the PSA test to " patient source of anxiety" . Lordy !!! I dont get great sleep about 10 days prior . SO , I will take it Mid Sept. The tend has been good and I need it to continue . The whole anxiety situation is more or less from dealing with my father and his prostate discovery about 28 years ago or so. I remember it like yesterday. He was a chemical engineer and a very bright guy, but he hated going to the doctors as he said it was not an exact science and they can get you into trouble. When he had to get a physical for an overseas trip, they snagged him at that point. I think he was at 14 to 17 on the PSA. Who knows how long he had it for. He was 60 at the time. One year younger than myself. I drove him to his appointment and cancelled him and gave him books on topic, etc. The last year was the toughest. He elected to do External beam radiation as his only treatment. Then he went on hormone therapy prior to his death about one year. That was tough to witness. I would come up to the hospital in the palliative care ward and bring some of his favourite foods or treats, at times he would smile and other times he would smile and say, "...I wish I had the appetite and my taste buds to eat that ..." . It was like yesterday for sure Sir . God Bless you and yours . . James on Vancouver Island .

Jump to this post

You can diminish your PSA anxiety by eating lots of mushrooms a few days before the PSA check. Works for me. Mine is < .01. Look it up: MUSHROOMS lowers PSA.

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Is there anybody with a 4+3 Gleason score who chose Cyberknife? I’d like to know thoughts and results. Thanks

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Hi I have Gleason 3+4 in less then 10% of 1 core and 3+3 in less 25% of another core I have been on active surveillance for almost 3 years

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