Isamac,I am kinda in the same boat wondering the same. My oncologist does not know why. However, he thinks something is changing in our gut/microbiome health. I'm 48 yoa police officer was diagnosed with stage 3B colon cancer under went r hemlectomy resection and 6 months of Oxi/ Fu. Was doing fine besides the 23 pound weight gain and neuropathy etc. Just recent signaterra test value came back at 1. I'm n shock hasn't even been 4 months since I finished treatment. Scans are negative so far feels like it was all for nothing. I thought I would get a couple years wo having to deal with Dr again. Short answer is no one knows. Been active all my life was looking out for prostate cancer since father had it. No issues whatsoever, Sept 5, 2023 had a dull pain in abdomen while watching TV. Went to urgent care diagnosed with a small bowel obstruction transferred to a hospital. The rest is history. Still in shock. Just tell him to research and look into his oncologist they are all not created equal. Be essed and Goodluck.