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@hrojzen0922

If the objective of the NAD drip is to boost the pathway that ultimately supports mitochondrial ATP production (ATP being the primary source of energy across a very wide range of metabolic functions), I wonder whether your naturopath (a classical homeopath would not typically prescribe a nutraceutical drip) might consider something easier to pursue over a long period that could potentially be as effective in boosting your ATP production, i.e., thiamine repletion/supplementation therapy. Thiamine therapy can usually be done with oral supplements, though in hospital settings, thiamine/B1 drips are available and in use for multiple conditions.

There are multiple nutrients that are indispensable to ATP production, and NAD is surely one of them, but NAD is a derivative of more basic nutrients that are available from foods and OTC supplements, and NAD is farther downstream than, e.g., thiamine, in the ATP production pathway.

Like thiamine, magnesium is indispensable to normal ATP metabolism, and because the nutrients essential in metabolic pathways always work together, when one pursues thiamine supplementation, itś important also to increase oneś magnesium intake (with magnesium taurate being the most commonly advised version for this purpose).

Iḿ impressed that your naturopath sees that COVID damages our metabolism at quite basic levels, calling for treatments that address something as deep as mitochondrial function (which encompasses ATP synthesis), but after trying lots of downstream ¨energy-boosting¨ supplements (including choline), my non-response to these told me that I needed to go to a deeper deficiency or defect in order to get my energy up. That thiamine is essential not only in ATP production, but also in acetylcholine production, clued me in to the likelihood that any defect in my cellular thiamine levels, or in the way my thiamine was being metabolized, could be causing problems not limited to disrupted ATP production.

The work of orthomolecular therapy physician and researcher Derrick Lonsdale confirmed my suspicions, and then set forth, for me, the massive scale and diversity of dysfunction that thiamine deficiency/defect in the human body can cause.

In any case, if your naturopath is familiar with all this, and you decide to inquire about it with your naturopath, please consider showing your naturopath at least some sample chapters of Lonsdaleś crowning work titled Thiamine Deficiency Disease, Dysautonomia, and High-Calorie Malnutrition (written with Dr. Chandler Marrs). This work focuses on subacute thiamine deficiency and advocates thiamine supplementation in patients exhibiting the symptoms of B1 deficiency regardless of their thiamine lab values. Before his death, Dr. Lonsdale published an important article in which he posited that the COVID virus was involved in harming some component of the pathways of thiamine storage and deployment, and while no research on this existed at the time of this hypothesis, he cited as precedent the fact that many viruses other than COVID are well known to produce post-viral syndromes that involve energy deficits (e.g., Epstein-Barr chronic fatigue and myalgia).

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Replies to "If the objective of the NAD drip is to boost the pathway that ultimately supports mitochondrial..."

Thank you for your thorough reply. Without the background to completely understand the entirety of your response I have been considering seeking out a naturopath. My experience with COVID and the resulting Paxlovid treatment resulted in the almost complete resolution of my symptoms of Osteoporosis . Arthritis, etc. there is a complete discussion of this phenomenon on this website. We are all waving our arms and saying “Please look at this miracle” but no one in the medical field will say anything but “Hmmm”? Same response from the manufacturer.
Any ideas on this phenomenon?

Just finished a month on the 600 mg of thiamine, with Mg ( and a host of other vits/ mins) …do you think I should have noticed any improvement (LC (postural hypotension with hypertension sitting is the symptom I’d like most to improve)? Have gone back to a BComplex with 110 mg Thiamin per pill. Tried getting to read the Lonsdale stuff but behind a paywall….so limited knowledge of protocol.