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Polymyalgia Rheumatica (PMR) | Last Active: Aug 28 6:49am | Replies (16)
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dadcue is better educated than me but side effects are really person to person. I have heard those that say they have no side effects from prednisone. I had high A1C, gastritis, High Cholesterol, high BP and weight gain in 6 months. Lots of people take statins. I can take them and have reactions in days. So its really how well your body tolerates it. With MTX is have seen high liver function tests from the comments. I dont think they know all the side effects from the Biologics yet. They are newer.
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Many of the side effects from prednisone are silent. People just aren't aware that some of their medical problems are being caused by prednisone. Your experience with your wife allows you to observe what happens when people are on long term corticosteroids.
I remember someone who claimed to know everything about PMR and prednisone simply based on their experience with having PMR for a long time and reading on a forum. She said the side effects are easy to manage if you know how. She said in all her years of experience she had never heard of a case of "steroid psychosis." I suggested she should actually take care of patients in a hospital setting who are admitted to the hospital for this very reason. I have seen hundreds of cases in just my little corner of the world.
"Psychiatric symptoms have been documented in association with the use of corticosteroids since these agents were first introduced in the 1950s.2 Corticosteroid-induced psychosis refers to a spectrum of psychiatric symptoms ranging from subtle mood changes to memory deficits to frank psychosis that can occur at any time during treatment (See Figure 1, p. 40).3 Mania and hypomania are reported most commonly (35%), followed by depressive symptoms (28%) and psychotic reactions (24%).2 Psychiatric symptoms typically develop three to four days after the initiation of corticosteroid therapy, although symptoms can occur at any time, including after cessation of therapy."
https://www.the-rheumatologist.org/article/when-steroids-cause-psychosis/?singlepage=1%26theme=print-friendly#:~:text=Corticosteroid%2Dinduced%20psychosis%20refers%20to,40).
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For the longest time I thought I was tolerating prednisone well. It wasn't until the adrenal suppression issue was brought to my attention that I became more aware. I used to think, I knew what I was doing but then I realized I had no clue whatsoever.
I became more aware of everything prednisone was doing to me when I did my own retrospective review of my medical history after I got off prednisone. Electronic medical records had every communication I had with my doctors not to mention every lab test, x-ray, CT scan, MRI and all of those kinds of things.