I would probably pick Kevzara if I had to do it over again. As Dadcue mentioned. Its an IL-6 inhibitor which has been found to be elevated in PMR patients. But my choice would be this instead of prednisone. You have already made the choice of prednisone. Neither of these additional drugs directly help with your cortisol restart. You will still have to fight through the taper. The purpose of the other drugs is to keep you from restarting PMR while tapering. Is it worth taking both if it might help? Probably. Kevzara can be stopped once you finish the prednisone if the PMR is inactive. Most people have PMR burn out where the drugs are not required. Dadcue has had trouble. Methotrexate might work and save you the money. Especially since you will be doing both. Sorry sort of wishy washy answer.