It isn't really a choice between two medications because nobody will know what will work the best for you. The choice boils down to WHEN do you want to move away from taking Prednisone and progress to a conventional DMARD (methotrexate) versus a biologic DMARD (Kevzara). It is more of a progression from Prednisone to a conventional DMARD or a biologic DMARD.

From my experience, if I could do it all over again, I would skip Prednisone and Methotrexate and go directly to a biologic DMARD (Kevzara) even though I only have experience with Actemra. Having the advantage of hindsight makes the call easier for me.

Depending on your rheumatolgist and/or insurance you may need to try methotrexate first before progressing to Kevzara. Your choice at the moment might be how long do you want to stick with Prednisone.